ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ap3m2

Full Name:

adaptor-related protein complex 3, mu 2 subunit

Alias:

MGC93230

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

16q12.5

Physical Location:

73688382-73706160 on NC_005115.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10947 Symbol (Name): AP3M2 (adaptor-related protein complex 3, mu 2 subunit)

Ortholog Status:

The human GeneID 10947 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ap3m2
Fold Change:		-1.11
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133305.2	NP_579839.1	NC_005115.2 range: 73688382..73706160

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IEA
GO:0030131	clathrin adaptor complex	Cellular Component	IEA
GO:0030117	membrane coat	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0008565	protein transporter activity	Molecular Function	IEA
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0007269	neurotransmitter secretion	Biological Process	NAS (8076832)
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006461	protein complex assembly	Biological Process	IEA
GO:0046907	intracellular transport	Biological Process	NAS (8076832)