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Gene Information
Gene ID:140667
Full Name:adaptor-related protein complex 3, mu 2 subunit
Organism:Rattus norvegicus (Rat)
Genetic Location:16q12.5
Physical Location:73688382-73706160 on NC_005115.2
Gene Type:protein-coding
Human Ortholog:GeneID: 10947    Symbol (Name): AP3M2 (adaptor-related protein complex 3, mu 2 subunit)
Ortholog Status:The human GeneID 10947 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ap3m2
Fold Change:-1.11
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_133305.2NP_579839.1NC_005115.2 range: 73688382..73706160
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0031410cytoplasmic vesicleCellular ComponentIEA
GO:0030659cytoplasmic vesicle membraneCellular ComponentIEA
GO:0030131clathrin adaptor complexCellular ComponentIEA
GO:0030117membrane coatCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0008565protein transporter activityMolecular FunctionIEA
GO:0016192vesicle-mediated transportBiological ProcessIEA
GO:0007269neurotransmitter secretionBiological ProcessNAS (8076832)
GO:0006886intracellular protein transportBiological ProcessIEA
GO:0006461protein complex assemblyBiological ProcessIEA
GO:0046907intracellular transportBiological ProcessNAS (8076832)
Other Database Cross Links
NCBI Entrez Gene:140667