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Gene Information
Gene ID:14083
Symbol:Ptk2
Full Name:PTK2 protein tyrosine kinase 2
Alias:FAK|FRNK|Fadk|KIAA4203|mKIAA4203
Organism:Mus musculus (Mouse)
Chromosome:15
Genetic Location:15 D3|15 42.0 cM
Physical Location:73035535-73225153 on NC_000081.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5747    Symbol (Name): PTK2 (PTK2 protein tyrosine kinase 2)
Ortholog Status:The human GeneID 5747 is also in human dataset(s).
Gene in Ethanol Study Datasets
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Lore5Alcohol-induced Loss of Righting Reflex15 18.8-61.7 (cM)4 SignificantPARC
Aaq1/EtaccAlcohol Acceptance153015-48 (cM)3.8 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007982.1NP_032008.1NC_000081.5 range: 73035535..73225153, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016324apical plasma membraneCellular ComponentIDA (10742111)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005925focal adhesionCellular ComponentIDA (10699171|11784865|15728191|16405917)
GO:0030054cell junctionCellular ComponentIEA
GO:0030027lamellipodiumCellular ComponentIDA (15728191)
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (7479864|9461600)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0004715non-membrane spanning protein tyrosine kinase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0004713protein-tyrosine kinase activityMolecular FunctionIEA
GO:0030198extracellular matrix organization and biogenesisBiological ProcessIMP (14642275)
GO:0040023establishment of nucleus localizationBiological ProcessIDA (12941275)
GO:0046621negative regulation of organ growthBiological ProcessIGI (16374517)
GO:0021955central nervous system neuron axonogenesisBiological ProcessIMP (15378065)
GO:0046777protein amino acid autophosphorylationBiological ProcessIMP (2132399)
GO:0050771negative regulation of axonogenesisBiological ProcessIMP (15378065)
GO:0043542endothelial cell migrationBiological ProcessIMP (15967814)
GO:0007229integrin-mediated signaling pathwayBiological ProcessTAS (11784865)
GO:0000226microtubule cytoskeleton organization and biogenesisBiological ProcessIDA (12941275)
GO:0001525angiogenesisBiological ProcessIMP (15967814)
GO:0001568blood vessel developmentBiological ProcessIMP (12595342|15967814)
GO:0001570vasculogenesisBiological ProcessIMP (15967814)
GO:0001764neuron migrationBiological ProcessIDA (12941275)
GO:0001764neuron migrationBiological ProcessIMP (14642275)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0006928cell motilityBiological ProcessTAS (11784865)
GO:0007172signal complex assemblyBiological ProcessIEA
GO:0051964negative regulation of synaptogenesisBiological ProcessIMP (15378065)
Other Database Cross Links
NCBI Entrez Gene:14083
MGI:
Ensembl:ENSMUSG00000022607
dbSNP:Ptk2
AceView:Ptk2