ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PTK2

Full Name:

PTK2 protein tyrosine kinase 2

Alias:

FADK|FAK|FAK1|pp125FAK

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8q24-qter

Physical Location:

141737682-142080513 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14083 Rat: 25614 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.395482
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

PTK2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	TAS (10801330)
GO:0030054	cell junction	Cellular Component	IEA
GO:0005925	focal adhesion	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (9325343)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IEA
GO:0042169	SH2 domain binding	Molecular Function	IPI (15077193)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (8649368\|10822899\|14688263)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IC (8422239)
GO:0007229	integrin-mediated signaling pathway	Biological Process	TAS (9636140)
GO:0007172	signal complex assembly	Biological Process	IEA