ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ptk2

Full Name:

PTK2 protein tyrosine kinase 2

Alias:

FAK|FRNK

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q34

Physical Location:

110933298-111084553 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5747 Symbol (Name): PTK2 (PTK2 protein tyrosine kinase 2)

Ortholog Status:

The human GeneID 5747 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ptk2
Fold Change:		1.12
P Value:		0.007
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013081.1	NP_037213.1	NC_005106.2 range: 110933298..111084553, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005925	focal adhesion	Cellular Component	TAS (8738136)
GO:0030027	lamellipodium	Cellular Component	ISS
GO:0016324	apical plasma membrane	Cellular Component	ISS
GO:0005925	focal adhesion	Cellular Component	ISS
GO:0042169	SH2 domain binding	Molecular Function	ISS
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IDA (16690621)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	TAS (8738136)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0050771	negative regulation of axonogenesis	Biological Process	ISS
GO:0046777	protein amino acid autophosphorylation	Biological Process	ISS
GO:0046621	negative regulation of organ growth	Biological Process	ISS
GO:0043542	endothelial cell migration	Biological Process	ISS
GO:0000226	microtubule cytoskeleton organization and biogenesis	Biological Process	ISS
GO:0040023	establishment of nucleus localization	Biological Process	ISS
GO:0030198	extracellular matrix organization and biogenesis	Biological Process	ISS
GO:0001525	angiogenesis	Biological Process	ISS
GO:0021955	central nervous system neuron axonogenesis	Biological Process	ISS
GO:0001568	blood vessel development	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0001570	vasculogenesis	Biological Process	ISS
GO:0001764	neuron migration	Biological Process	ISS
GO:0051964	negative regulation of synaptogenesis	Biological Process	ISS