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Gene Information
Gene ID:140910
Symbol:Sc4mol
Full Name:sterol-C4-methyl oxidase-like
Organism:Rattus norvegicus (Rat)
Chromosome:16
Genetic Location:16p13
Physical Location:26698323-26716246 on NC_005115.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6307    Symbol (Name): SC4MOL (sterol-C4-methyl oxidase-like)
Ortholog Status:The human GeneID 6307 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.7167
Original ID2:Sc4mol
Fold Change:1.15
P Value:0.00004
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_080886.1NP_543162.1NC_005115.2 range: 26698323..26716246
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0000254C-4 methylsterol oxidase activityMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0008152metabolic processBiological ProcessIEA
GO:0016126sterol biosynthetic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:140910
RGD:620281
Ensembl:ENSRNOG00000032297
dbSNP:Sc4mol