ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

As3mt

Full Name:

arsenic (+3 oxidation state) methyltransferase

Alias:

Cyt19

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q54

Physical Location:

252029637-252061351 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 57412 Symbol (Name): AS3MT (arsenic (+3 oxidation state) methyltransferase)

Ortholog Status:

The human GeneID 57412 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		As3mt
Fold Change:		1.13
P Value:		0.006
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080890.1	NP_543166.1	NC_005100.2 range: 252029637..252061351

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005625	soluble fraction	Cellular Component	IDA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IDA (11790780)
GO:0030792	methylarsonite methyltransferase activity	Molecular Function	IDA
GO:0030791	arsenite methyltransferase activity	Molecular Function	IDA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Molecular Function	TAS (11790780)
GO:0008276	protein methyltransferase activity	Molecular Function	TAS (11790780)
GO:0008168	methyltransferase activity	Molecular Function	IEA
GO:0009404	toxin metabolic process	Biological Process	IDA
GO:0018872	arsonoacetate metabolic process	Biological Process	IDA
GO:0008152	metabolic process	Biological Process	IEA
GO:0046685	response to arsenic	Biological Process	IDA