ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

14104

Symbol:

Fasn

Full Name:

fatty acid synthase

Alias:

A630082H08Rik|FAS

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 E2|11 72.0 cM

Physical Location:

120667271-120685860 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2194 Symbol (Name): FASN (fatty acid synthase)

Ortholog Status:

The human GeneID 2194 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fasn
Fold Change:		1.52
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007988.3	NP_032014.3	NC_000077.5 range: 120667271..120685860, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0042587	glycogen granule	Cellular Component	IDA (15169678)
GO:0048037	cofactor binding	Molecular Function	IEA
GO:0008415	acyltransferase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016788	hydrolase activity, acting on ester bonds	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0031177	phosphopantetheine binding	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Molecular Function	IEA
GO:0004312	fatty-acid synthase activity	Molecular Function	IEA
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Molecular Function	IEA
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Molecular Function	IEA
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Molecular Function	IEA
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase activity	Molecular Function	IEA
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Molecular Function	IEA
GO:0006633	fatty acid biosynthetic process	Biological Process	IEA
GO:0009058	biosynthetic process	Biological Process	IEA
GO:0008610	lipid biosynthetic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA