ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

2194

Symbol:

FASN

Full Name:

fatty acid synthase

Alias:

FAS|MGC14367|MGC15706|OA-519

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25

Physical Location:

77629502-77649394 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14104 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

FASN

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004104.4	NP_004095.4	NC_000017.9 range: 77629502..77649394, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042470	melanosome	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (7567999\|12815048)
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Molecular Function	EXP (7567999)
GO:0005515	protein binding	Molecular Function	IPI (17220478)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016788	hydrolase activity, acting on ester bonds	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0031177	phosphopantetheine binding	Molecular Function	IEA
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Molecular Function	IEA
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Molecular Function	EXP (7567999)
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Molecular Function	IEA
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Molecular Function	IEA
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Molecular Function	EXP (7567999)
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Molecular Function	IEA
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Molecular Function	EXP (7567999)
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Molecular Function	IEA
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase activity	Molecular Function	EXP (7567999)
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase activity	Molecular Function	IEA
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Molecular Function	IEA
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Molecular Function	EXP (7567999)
GO:0048037	cofactor binding	Molecular Function	IEA
GO:0006633	fatty acid biosynthetic process	Biological Process	IEA