ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ppm1g

Full Name:

protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform

Alias:

AI385652|Fin13

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 B1|5 19.0 cM

Physical Location:

31505040-31522917 on NC_000071.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5496 Symbol (Name): PPM1G (protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform)

Ortholog Status:

The human GeneID 5496 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ppm1g
Original ID2:		U42383

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008014.3	NP_032040.1	NC_000071.5 range: 31505040..31522917, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008287	protein serine/threonine phosphatase complex	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (9271424)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	IEA
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IDA (9271424)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IDA (9271424)
GO:0007050	cell cycle arrest	Biological Process	IDA (9271424)
GO:0007049	cell cycle	Biological Process	IEA