ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ctgf

Full Name:

connective tissue growth factor

Alias:

Ccn2|Fisp12|Hcs24|fisp-12

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 A3-B1|10 17.0 cM

Physical Location:

24315312-24318485 on NC_000076.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1490 Symbol (Name): CTGF (connective tissue growth factor)

Ortholog Status:

The human GeneID 1490 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ctgf
Original ID2:		M70642

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010217.2	NP_034347.2	NC_000076.5 range: 24315312..24318485

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IDA (9184077)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005576	extracellular region	Cellular Component	IDA (1888698)
GO:0005520	insulin-like growth factor binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005178	integrin binding	Molecular Function	IDA (10446209)
GO:0008201	heparin binding	Molecular Function	IDA (9184077)
GO:0007229	integrin-mediated signaling pathway	Biological Process	IDA (10082563\|10446209)
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	IDA (9184077)
GO:0007160	cell-matrix adhesion	Biological Process	IDA (9184077)
GO:0016477	cell migration	Biological Process	IDA (10082563)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006260	DNA replication	Biological Process	IEA
GO:0001502	cartilage condensation	Biological Process	IDA (15305294)
GO:0001558	regulation of cell growth	Biological Process	IEA
GO:0001525	angiogenesis	Biological Process	IMP (12736220)
GO:0001525	angiogenesis	Biological Process	IDA (10082563\|10446209)
GO:0001503	ossification	Biological Process	IMP (11237711\|12736220)
GO:0030154	cell differentiation	Biological Process	IDA (15305294)