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Gene Information
Gene ID:14219
Full Name:connective tissue growth factor
Organism:Mus musculus (Mouse)
Genetic Location:10 A3-B1|10 17.0 cM
Physical Location:24315312-24318485 on NC_000076.5
Gene Type:protein-coding
Human Ortholog:GeneID: 1490    Symbol (Name): CTGF (connective tissue growth factor)
Ortholog Status:The human GeneID 1490 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ctgf
Original ID2:M70642
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010217.2NP_034347.2NC_000076.5 range: 24315312..24318485
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005578proteinaceous extracellular matrixCellular ComponentIDA (9184077)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005576extracellular regionCellular ComponentIDA (1888698)
GO:0005520insulin-like growth factor bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005178integrin bindingMolecular FunctionIDA (10446209)
GO:0008201heparin bindingMolecular FunctionIDA (9184077)
GO:0007229integrin-mediated signaling pathwayBiological ProcessIDA (10082563|10446209)
GO:0008543fibroblast growth factor receptor signaling pathwayBiological ProcessIDA (9184077)
GO:0007160cell-matrix adhesionBiological ProcessIDA (9184077)
GO:0016477cell migrationBiological ProcessIDA (10082563)
GO:0007155cell adhesionBiological ProcessIEA
GO:0006260DNA replicationBiological ProcessIEA
GO:0001502cartilage condensationBiological ProcessIDA (15305294)
GO:0001558regulation of cell growthBiological ProcessIEA
GO:0001525angiogenesisBiological ProcessIMP (12736220)
GO:0001525angiogenesisBiological ProcessIDA (10082563|10446209)
GO:0001503ossificationBiological ProcessIMP (11237711|12736220)
GO:0030154cell differentiationBiological ProcessIDA (15305294)
Other Database Cross Links
NCBI Entrez Gene:14219