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Gene Information
Gene ID:14229
Symbol:Fkbp5
Full Name:FK506 binding protein 5
Alias:51kDa|D17Ertd592e|Dit1|FKBP51
Organism:Mus musculus (Mouse)
Chromosome:17
Genetic Location:17 A3.3|17 13.0 cM
Physical Location:28536041-28578002 on NC_000083.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2289    Symbol (Name): FKBP5 (FK506 binding protein 5)
Ortholog Status:The human GeneID 2289 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U16959
Fold Change:2.0, 2.5, 2.3, 3.0
Note:4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2
Dataset Information
Name:15002731
Method:Microarray
Tissue:Whole brain
Phenotype:Acute ethanol response
Publication:Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.
Gene Information
Original ID1:Fkbp5
Original ID2:U16959
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010220.2NP_034350.1NC_000083.5 range: 28536041..28578002, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0003755peptidyl-prolyl cis-trans isomerase activityMolecular FunctionIEA
GO:0005488bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (11751894)
GO:0016853isomerase activityMolecular FunctionIEA
GO:0006457protein foldingBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:14229
MGI:
Ensembl:ENSMUSG00000024222
dbSNP:Fkbp5
AceView:Fkbp5