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Gene Information
Gene ID:14265
Symbol:Fmr1
Full Name:fragile X mental retardation syndrome 1 homolog
Alias:FMRP|Fmr-1
Organism:Mus musculus (Mouse)
Chromosome:X
Genetic Location:X A7.1|X 24.5 cM
Physical Location:65931729-65971137 on NC_000086.6
Gene Type:protein-coding
Human Ortholog:GeneID: 2332    Symbol (Name): FMR1 (fragile X mental retardation 1)
Ortholog Status:The human GeneID 2332 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Fmr1
Original ID2:L23971
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008031.2NP_032057.2NC_000086.6 range: 65931729..65971137
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (12700164)
GO:0005737cytoplasmCellular ComponentIEA
GO:0003723RNA bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (11438699)
GO:0006810transportBiological ProcessIEA
GO:0007417central nervous system developmentBiological ProcessIMP (12700164)
GO:0051028mRNA transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:14265
MGI:
Ensembl:ENSMUSG00000000838
dbSNP:Fmr1
AceView:Fmr1