ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fmr1

Full Name:

fragile X mental retardation syndrome 1 homolog

Alias:

FMRP|Fmr-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X A7.1|X 24.5 cM

Physical Location:

65931729-65971137 on NC_000086.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2332 Symbol (Name): FMR1 (fragile X mental retardation 1)

Ortholog Status:

The human GeneID 2332 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fmr1
Original ID2:		L23971

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008031.2	NP_032057.2	NC_000086.6 range: 65931729..65971137

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12700164)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11438699)
GO:0006810	transport	Biological Process	IEA
GO:0007417	central nervous system development	Biological Process	IMP (12700164)
GO:0051028	mRNA transport	Biological Process	IEA