| Gene Information |
| Gene ID: | | 14296 |
| Symbol: | | Frat1 |
| Full Name: | | frequently rearranged in advanced T-cell lymphomas |
| Alias: | | AW060382 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 19 |
| Genetic Location: | | 19 C3|19 37.5 cM |
| Physical Location: | | 41904605-41907072 on NC_000085.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 10023 Symbol (Name): FRAT1 (frequently rearranged in advanced T-cell lymphomas) |
| Ortholog Status: | | The human GeneID 10023 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | U58974 | | Note: | | Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains |
| | Dataset Information | | Name: | | 15282116 | | Method: | | Microarray | | Tissue: | | Striata | | Phenotype: | | Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration | | Publication: | | Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed | | Summary: | | Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By. |
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| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Calw2/Alcdp2 | Chronic Alcohol Withdrawal | 19 | 47 | 36.5-ter (cM) | 5.3 | 6.00E-07 | Significant | PARC |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0000578 | embryonic axis specification | Biological Process | IDA (10534617) | |
| GO:0016055 | Wnt receptor signaling pathway | Biological Process | IGI (15681612) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 14296 |
| MGI: | |
| Ensembl: | | ENSMUSG00000067199 |
| dbSNP: | | Frat1 |
| AceView: | | Frat1 |
