ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PARP4

Full Name:

poly (ADP-ribose) polymerase family, member 4

Alias:

ADPRTL1|PARPL|PH5P|VAULT3|VPARP|p193

Organism:

Homo sapiens (Human)

Chromosome:

13

Genetic Location:

13q11

Physical Location:

23893068-23984947 on NC_000013.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

NM_006437

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006437.3	NP_006428.2	NC_000013.9 range: 23893068..23984947, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	NAS (10644454)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0030529	ribonucleoprotein complex	Cellular Component	NAS (11479319)
GO:0003677	DNA binding	Molecular Function	TAS (10100603)
GO:0003950	NAD+ ADP-ribosyltransferase activity	Molecular Function	NAS (10644454)
GO:0019899	enzyme binding	Molecular Function	IDA (15169895)
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0008219	cell death	Biological Process	IMP (12140175)
GO:0006954	inflammatory response	Biological Process	IMP (12123754)
GO:0006810	transport	Biological Process	NAS (11855821)
GO:0006471	protein amino acid ADP-ribosylation	Biological Process	NAS (10644454)
GO:0006464	protein modification process	Biological Process	TAS (10100603)
GO:0006281	DNA repair	Biological Process	NAS (12101391)
GO:0042493	response to drug	Biological Process	NAS (11291045)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000102699

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: