ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

14387

Symbol:

Gaa

Full Name:

glucosidase, alpha, acid

Alias:

E430018M07Rik

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 D-E|11 74.0 cM

Physical Location:

119129357-119146765 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2548 Symbol (Name): GAA (glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II))

Ortholog Status:

The human GeneID 2548 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gaa
Original ID2:		U49351

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008064.2	NP_032090.2	NC_000077.5 range: 119129357..119146765

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005764	lysosome	Cellular Component	IMP (15207257)
GO:0005764	lysosome	Cellular Component	TAS (11785984)
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Molecular Function	IEA
GO:0004558	alpha-glucosidase activity	Molecular Function	IDA (7323947)
GO:0004558	alpha-glucosidase activity	Molecular Function	IMP (9384603\|9668092\|11328962\|11590121\|11785984\|15169761)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016798	hydrolase activity, acting on glycosyl bonds	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0009888	tissue development	Biological Process	IMP (10547605)
GO:0002026	regulation of the force of heart contraction	Biological Process	IMP (11328962)
GO:0046716	muscle maintenance	Biological Process	IMP (9668092\|10547605\|10838256\|12115977\|15674828)
GO:0050884	neuromuscular process controlling posture	Biological Process	IMP (10547605)
GO:0007626	locomotory behavior	Biological Process	IMP (9668092\|10547605\|10838256)
GO:0007040	lysosome organization and biogenesis	Biological Process	IMP (9384603\|9668092\|10547605\|11328962\|12115977\|15169761)
GO:0006941	striated muscle contraction	Biological Process	IMP (12115977\|15674828)
GO:0005980	glycogen catabolic process	Biological Process	IMP (10838256\|11328962\|11785984)
GO:0005977	glycogen metabolic process	Biological Process	IMP (9384603\|9668092\|10547605\|11590121\|12115977\|15169761\|15207257)
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0003007	heart morphogenesis	Biological Process	IMP (9384603)
GO:0002086	diaphragm contraction	Biological Process	IMP (15169761)
GO:0050885	neuromuscular process controlling balance	Biological Process	IMP (10838256)