ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gabrb1

Full Name:

gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1

Alias:

AW061132|Gabrb-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 C3.2|5 40.0 cM

Physical Location:

72091254-72528482 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2560 Symbol (Name): GABRB1 (gamma-aminobutyric acid (GABA) A receptor, beta 1)

Ortholog Status:

The human GeneID 2560 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gabrb1
Original ID2:		U14418

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008069.4	NP_032095.1	NC_000071.5 range: 72091254..72528482

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005254	chloride channel activity	Molecular Function	IEA
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004890	GABA-A receptor activity	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA