ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gbx2

Full Name:

gastrulation brain homeobox 2

Alias:

D130058E05Rik|Gbx-2|MMoxA|Stra7

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 C5-E1|1 65.0 cM

Physical Location:

91824536-91827750 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2637 Symbol (Name): GBX2 (gastrulation brain homeobox 2)

Ortholog Status:

The human GeneID 2637 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gbx2
Original ID2:		Z48800

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010262.3	NP_034392.1	NC_000067.5 range: 91824536..91827750, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0001569	patterning of blood vessels	Biological Process	IGI (15996652)
GO:0021930	granule cell precursor proliferation	Biological Process	IMP (16651541)
GO:0030902	hindbrain development	Biological Process	IMP (15829521\|16651541)
GO:0030917	midbrain-hindbrain boundary development	Biological Process	IMP (16651541)
GO:0035239	tube morphogenesis	Biological Process	IMP (15996652)
GO:0042472	inner ear morphogenesis	Biological Process	IMP (15829521\|15996652)
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0021568	rhombomere 2 development	Biological Process	IMP (16651541)
GO:0021555	midbrain-hindbrain boundary morphogenesis	Biological Process	IMP (16651541)
GO:0021549	cerebellum development	Biological Process	IMP (16651541)
GO:0008283	cell proliferation	Biological Process	IMP (16651541)
GO:0007411	axon guidance	Biological Process	IMP (11967891)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0001755	neural crest cell migration	Biological Process	IMP (15996652)
GO:0001569	patterning of blood vessels	Biological Process	IMP (15996652)
GO:0048483	autonomic nervous system development	Biological Process	IMP (15996652)