ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

14654

Symbol:

Glra1

Full Name:

glycine receptor, alpha 1 subunit

Alias:

B230397M16Rik|nmf11|oscillator|ot|spasmodic|spd

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B1.3|11 30.0 cM

Physical Location:

55328314-55421291 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2741 Symbol (Name): GLRA1 (glycine receptor, alpha 1)

Ortholog Status:

The human GeneID 2741 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws4/Alcw3	Chronic Alcohol Withdrawal	11		15-36 (cM)	6.7	2.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020492.3	NP_065238.2	NC_000077.5 range: 55328314..55421291, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IDA (17145751)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IDA (9145798)
GO:0005624	membrane fraction	Cellular Component	IDA (1371219\|17114051)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0030054	cell junction	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	IDA (17145751)
GO:0045202	synapse	Cellular Component	IEA
GO:0045211	postsynaptic membrane	Cellular Component	IDA (16964444\|17114051)
GO:0016934	extracellular-glycine-gated chloride channel activity	Molecular Function	IMP (16672662)
GO:0016594	glycine binding	Molecular Function	IDA (7874121)
GO:0016594	glycine binding	Molecular Function	IMP (8062927\|9145798)
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0016594	glycine binding	Molecular Function	ISO
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0016934	extracellular-glycine-gated chloride channel activity	Molecular Function	IDA (8062927)
GO:0016934	extracellular-glycine-gated chloride channel activity	Molecular Function	ISO
GO:0016934	extracellular-glycine-gated chloride channel activity	Molecular Function	ISO
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004890	GABA-A receptor activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005254	chloride channel activity	Molecular Function	IEA
GO:0042391	regulation of membrane potential	Biological Process	IDA (8062927)
GO:0001964	startle response	Biological Process	IMP (8406478\|8733750\|9087981\|11275284\|12380014\|16964444\|17114051)
GO:0050884	neuromuscular process controlling posture	Biological Process	IMP (17114051)
GO:0043576	regulation of respiratory gaseous exchange	Biological Process	IMP (11742725\|12380014)
GO:0050905	neuromuscular process	Biological Process	IMP (9087981\|17114051)
GO:0060012	synaptic transmission, glycinergic	Biological Process	IMP (16672662)
GO:0060013	righting reflex	Biological Process	IMP (17114051)
GO:0042391	regulation of membrane potential	Biological Process	ISO
GO:0042391	regulation of membrane potential	Biological Process	IMP (16672662)
GO:0001964	startle response	Biological Process	ISO
GO:0002087	neurological control of breathing	Biological Process	IMP (16800867)
GO:0007601	visual perception	Biological Process	IMP (17114051)
GO:0007268	synaptic transmission	Biological Process	IMP (12837931)
GO:0006821	chloride transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0001508	regulation of action potential	Biological Process	IMP (11742725\|16800867)
GO:0007340	acrosome reaction	Biological Process	IMP (11076688)
GO:0007628	adult walking behavior	Biological Process	IMP (17114051)
GO:0060080	regulation of inhibitory postsynaptic membrane potential	Biological Process	IMP (17114051)