ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

2741

Symbol:

GLRA1

Full Name:

glycine receptor, alpha 1

Alias:

MGC138878|MGC138879|STHE

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q32

Physical Location:

151182360-151284595 on NC_000005.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14654 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

GLRA1

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Information

Original ID1:

GLRA1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000171.2	NP_000162.2	NC_000005.8 range: 151182360..151284595, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	IDA (7506679)
GO:0005887	integral to plasma membrane	Cellular Component	NAS (2155780)
GO:0005887	integral to plasma membrane	Cellular Component	IMP (11973623)
GO:0005887	integral to plasma membrane	Cellular Component	IDA (7506679)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0016594	glycine binding	Molecular Function	IDA (2155780\|15748848)
GO:0016934	extracellular-glycine-gated chloride channel activity	Molecular Function	IDA (2155780\|8137830)
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0030977	taurine binding	Molecular Function	IDA (15748848)
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11929858)
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004890	GABA-A receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0042391	regulation of membrane potential	Biological Process	IMP (7920629)
GO:0001964	startle response	Biological Process	IMP (8298642\|11973623)
GO:0007218	neuropeptide signaling pathway	Biological Process	IDA (2155780)
GO:0006936	muscle contraction	Biological Process	IMP (11973623)
GO:0006821	chloride transport	Biological Process	IDA (8137830)
GO:0006811	ion transport	Biological Process	IDA (2155780)
GO:0051970	negative regulation of transmission of nerve impulse	Biological Process	IMP (11973623)