ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gnai1

Full Name:

guanine nucleotide binding protein (G protein), alpha inhibiting 1

Alias:

AU046200|Gialpha1|Gnai-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 A3|5 2.0 cM

Physical Location:

17770952-17866230 on NC_000071.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2770 Symbol (Name): GNAI1 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1)

Ortholog Status:

The human GeneID 2770 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gnai1
Original ID2:		AI153412

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010305.1	NP_034435.1	NC_000071.5 range: 17770952..17866230, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IDA (16805845)
GO:0003924	GTPase activity	Molecular Function	TAS (2508088)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (2508088)