ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gnai2

Full Name:

guanine nucleotide binding protein (G protein), alpha inhibiting 2

Alias:

C76432|Galphai2|Gia|Gnai-2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F1|9 59.0 cM

Physical Location:

107516468-107537672 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2771 Symbol (Name): GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2)

Ortholog Status:

The human GeneID 2771 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gnai2
Original ID2:		M13963

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact2	Alcohol Stimulated Activity	9	61	51-71 (cM)	3.6	4.30E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008138.4	NP_032164.2	NC_000075.5 range: 107516468..107537672, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0019001	guanyl nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	ISS (3092218)
GO:0005515	protein binding	Molecular Function	IPI (8076637)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	TAS (2508088)
GO:0008283	cell proliferation	Biological Process	IPI (14712229)
GO:0008016	regulation of heart contraction	Biological Process	IMP (11158953)
GO:0007213	acetylcholine receptor signaling, muscarinic pathway	Biological Process	IMP (11299198)
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	Biological Process	ISS (3092218)
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	Biological Process	IMP (8622915)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (2508088)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	Biological Process	IGI (7706278)