ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gnao1

Full Name:

guanine nucleotide binding protein, alpha O

Alias:

AW050213|Gnao

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 C5|8 45.0 cM

Physical Location:

96334737-96493287 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2775 Symbol (Name): GNAO1 (guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O)

Ortholog Status:

The human GeneID 2775 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gnao
Original ID2:		AA259683

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010308.3	NP_034438.1	NC_000074.5 range: 96334737..96493287

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005834	heterotrimeric G-protein complex	Cellular Component	TAS (2508088)
GO:0005624	membrane fraction	Cellular Component	TAS (8078103)
GO:0005622	intracellular	Cellular Component	IDA (16805845)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0019001	guanyl nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IMP (11248120)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	TAS (2508088)
GO:0009987	cellular process	Biological Process	IMP (10570206)
GO:0008016	regulation of heart contraction	Biological Process	IMP (9050846)
GO:0007626	locomotory behavior	Biological Process	IMP (9501252)
GO:0007212	dopamine receptor signaling pathway	Biological Process	IMP (11248120)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (2508088)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IMP (9501252)
GO:0007165	signal transduction	Biological Process	IEA