Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:14688
Full Name:guanine nucleotide binding protein (G protein), beta 1
Organism:Mus musculus (Mouse)
Genetic Location:4 E2|4 79.4 cM
Physical Location:154901558-154933375 on NC_000070.5
Gene Type:protein-coding
Human Ortholog:GeneID: 2782    Symbol (Name): GNB1 (guanine nucleotide binding protein (G protein), beta polypeptide 1)
Ortholog Status:The human GeneID 2782 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U29055
Note:Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains
Dataset Information
Phenotype:Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.
Gene Information
Original ID1:Gnb1
Gene Information
Original ID1:1454696_at
Dataset Information
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
Gene Information
Original ID1:Gnb1
Fold Change:17.13
P Value:0
Note:alcohol preference
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Alcohol preference, acute functional tolerance
Publication:Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Ap3qAlcohol Preference Drinking47565-ter (cM)4.6 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008142.3NP_032168.1NC_000070.5 range: 154901558..154933375
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005834heterotrimeric G-protein complexCellular ComponentIPI (10570481)
GO:0005834heterotrimeric G-protein complexCellular ComponentISS (1543505)
GO:0003924GTPase activityMolecular FunctionISS (1543505)
GO:0003924GTPase activityMolecular FunctionRCA (12466851)
GO:0004871signal transducer activityMolecular FunctionRCA (12466851)
GO:0008283cell proliferationBiological ProcessIDA (14712229)
GO:0007603phototransduction, visible lightBiological ProcessISS (2328987)
GO:0007265Ras protein signal transductionBiological ProcessRCA (12466851)
GO:0007213acetylcholine receptor signaling, muscarinic pathwayBiological ProcessRCA (12466851)
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)Biological ProcessIDA (10570481)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (1543505)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIDA (14712229)
GO:0007165signal transductionBiological ProcessRCA (12466851)
GO:0050909sensory perception of tasteBiological ProcessIDA (10570481)
Other Database Cross Links
NCBI Entrez Gene:14688