ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

S1pr2

Full Name:

sphingosine-1-phosphate receptor 2

Alias:

1100001A16Rik|Edg5|Gpcr13|H218|LPb2|S1P2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 A3|9 6.0 cM

Physical Location:

20770401-20781224 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9294 Symbol (Name): S1PR2 (sphingosine-1-phosphate receptor 2)

Ortholog Status:

The human GeneID 9294 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Edg5
Original ID2:		AF108020

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010333.4	NP_034463.2	NC_000075.5 range: 20770401..20781224, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	Molecular Function	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007610	behavior	Biological Process	IMP (11553273)
GO:0007165	signal transduction	Biological Process	IEA