ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gpr50

Full Name:

G-protein-coupled receptor 50

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X A7.2|X 26.0 cM

Physical Location:

68916941-68921263 on NC_000086.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9248 Symbol (Name): GPR50 (G protein-coupled receptor 50)

Ortholog Status:

The human GeneID 9248 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gpr50
Original ID2:		AF065145

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010340.1	NP_034470.1	NC_000086.6 range: 68916941..68921263

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0008502	melatonin receptor activity	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA