ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

14775

Symbol:

Gpx1

Full Name:

glutathione peroxidase 1

Alias:

AI195024|AL033363|CGPx|GPx-1|GSHPx-1|Gpx

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F1|9 57.0 cM

Physical Location:

108241606-108242670 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2876 Symbol (Name): GPX1 (glutathione peroxidase 1)

Ortholog Status:

The human GeneID 2876 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact2	Alcohol Stimulated Activity	9	61	51-71 (cM)	3.6	4.30E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008160.5	NP_032186.2	NC_000075.5 range: 108241606..108242670

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IMP (10754271)
GO:0005739	mitochondrion	Cellular Component	IDA (9126277\|14651853)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0008430	selenium binding	Molecular Function	IEA
GO:0004602	glutathione peroxidase activity	Molecular Function	IDA (12521604\|12646716)
GO:0004602	glutathione peroxidase activity	Molecular Function	IMP (9386101\|9788901\|10490281\|10915565\|10915653\|11311045\|11518697\|11545230\|11893559\|12117267\|12751789\|151)
GO:0004601	peroxidase activity	Molecular Function	IEA
GO:0042542	response to hydrogen peroxide	Biological Process	IMP (14732290\|16373599)
GO:0042311	vasodilation	Biological Process	IMP (11893559\|12196344)
GO:0042744	hydrogen peroxide catabolic process	Biological Process	IMP (9788901\|10754271\|10915565\|11545230\|15182862\|15827346)
GO:0033194	response to hydroperoxide	Biological Process	IMP (16723478)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (16934683)
GO:0018158	protein amino acid oxidation	Biological Process	IMP (10428770)
GO:0043403	skeletal muscle regeneration	Biological Process	IMP (16962942)
GO:0043523	regulation of neuron apoptosis	Biological Process	IMP (11579147)
GO:0060055	angiogenesis involved in wound healing	Biological Process	IMP (16373599)
GO:0060047	heart contraction	Biological Process	IMP (12196344)
GO:0051897	positive regulation of protein kinase B signaling cascade	Biological Process	IMP (15663476)
GO:0051702	interaction with symbiont	Biological Process	IGI (12751789)
GO:0051450	myoblast proliferation	Biological Process	IMP (12368211\|16962942)
GO:0048741	skeletal muscle fiber development	Biological Process	IMP (16962942)
GO:0045444	fat cell differentiation	Biological Process	IMP (16962942)
GO:0043534	blood vessel endothelial cell migration	Biological Process	IMP (16373599)
GO:0007605	sensory perception of sound	Biological Process	IMP (11545230)
GO:0014902	myotube differentiation	Biological Process	IMP (12368211\|16962942)
GO:0010332	response to gamma radiation	Biological Process	IGI (15182862)
GO:0001885	endothelial cell development	Biological Process	IMP (16373599)
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Biological Process	IGI (12751789)
GO:0000302	response to reactive oxygen species	Biological Process	IMP (10915565\|11562367\|16373599\|16962942\|17145560)
GO:0006629	lipid metabolic process	Biological Process	IMP (10754271)
GO:0006641	triacylglycerol metabolic process	Biological Process	IMP (12117267)
GO:0006915	apoptosis	Biological Process	IMP (16962942)
GO:0006917	induction of apoptosis	Biological Process	IMP (16373599)
GO:0006979	response to oxidative stress	Biological Process	IGI (15182862)
GO:0006979	response to oxidative stress	Biological Process	IMP (10428770\|10627575\|10915565\|11893559\|12196344\|15182862\|16962942)
GO:0008283	cell proliferation	Biological Process	IMP (14732290)
GO:0008631	induction of apoptosis by oxidative stress	Biological Process	IMP (11562367\|15663476)
GO:0009410	response to xenobiotic stimulus	Biological Process	IMP (10915565)
GO:0009609	response to symbiotic bacterium	Biological Process	IGI (12751789)
GO:0009611	response to wounding	Biological Process	IMP (11579147)
GO:0009636	response to toxin	Biological Process	IMP (10627575)
GO:0001659	temperature homeostasis	Biological Process	IGI (11518697)