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Gene Information
Gene ID:14805
Symbol:Grik1
Full Name:glutamate receptor, ionotropic, kainate 1
Alias:A830007B11Rik|D16Ium24|D16Ium24e|Glur-5|Glur5|MGC25101
Organism:Mus musculus (Mouse)
Chromosome:16
Genetic Location:16 C3.3|16 58.0 cM
Physical Location:87896141-88290487 on NC_000082.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2897    Symbol (Name): GRIK1 (glutamate receptor, ionotropic, kainate 1)
Ortholog Status:The human GeneID 2897 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Grik1
Fold Change:0.77
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010348.3NP_034478.1NC_000082.5 range: 87896141..88290487, complement
NM_146072.4NP_666184.2NC_000082.5 range: 87896141..88290487, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0032983kainate selective glutamate receptor complexCellular ComponentIPI (17174564)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0008328ionotropic glutamate receptor complexCellular ComponentIC (12223554)
GO:0030054cell junctionCellular ComponentIEA
GO:0030425dendriteCellular ComponentIDA (17174564)
GO:0042734presynaptic membraneCellular ComponentIDA (11985817|14724198)
GO:0045202synapseCellular ComponentIEA
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIDA (15014126)
GO:0004872receptor activityMolecular FunctionIEA
GO:0015277kainate selective glutamate receptor activityMolecular FunctionIMP (12223554|15509753)
GO:0004970ionotropic glutamate receptor activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17174564)
GO:0015277kainate selective glutamate receptor activityMolecular FunctionIDA (15483117|17174564)
GO:0015277kainate selective glutamate receptor activityMolecular FunctionIGI (11985817)
GO:0006810transportBiological ProcessIEA
GO:0060080regulation of inhibitory postsynaptic membrane potentialBiological ProcessIGI (11144357)
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessIMP (11069933|14724198)
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessIGI (11985817)
GO:0051967negative regulation of synaptic transmission, glutamatergicBiological ProcessIGI (11985817)
GO:0048266behavioral response to painBiological ProcessIMP (15673679)
GO:0048172regulation of short-term neuronal synaptic plasticityBiological ProcessTAS (15537878)
GO:0048169regulation of long-term neuronal synaptic plasticityBiological ProcessTAS (15537878)
GO:0006811ion transportBiological ProcessIEA
GO:0042391regulation of membrane potentialBiological ProcessIMP (10516295|12223554|15509753|15513934)
GO:0042391regulation of membrane potentialBiological ProcessIDA (17174564)
GO:0035249synaptic transmission, glutamatergicBiological ProcessIMP (15509753|15928066)
GO:0035249synaptic transmission, glutamatergicBiological ProcessIGI (15928066)
GO:0060080regulation of inhibitory postsynaptic membrane potentialBiological ProcessIMP (12223554)
Other Database Cross Links
NCBI Entrez Gene:14805
MGI:
Ensembl:ENSMUSG00000022935
dbSNP:Grik1
AceView:Grik1