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Gene Information
Gene ID:2897
Full Name:glutamate receptor, ionotropic, kainate 1
Organism:Homo sapiens (Human)
Genetic Location:21q22.11
Physical Location:29831124-30234152 on NC_000021.7, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 14805 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:GRIK1
Dataset Information
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000830.3NP_000821.1NC_000021.7 range: 29831124..30234152, complement
NM_175611.2NP_783300.1NC_000021.7 range: 29831124..30234152, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (8260617)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionIEA
GO:0015277kainate selective glutamate receptor activityMolecular FunctionIDA (9335499)
GO:0007417central nervous system developmentBiological ProcessTAS (10580501)
GO:0007268synaptic transmissionBiological ProcessTAS (10580501)
GO:0007215glutamate signaling pathwayBiological ProcessTAS (8260617)
GO:0006811ion transportBiological ProcessIEA
GO:0051966regulation of synaptic transmission, glutamatergicBiological ProcessTAS (9335499)
Other Database Cross Links
NCBI Entrez Gene:2897
HuGE Navigator:2897