ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hspa5

Full Name:

heat shock protein 5

Alias:

78kDa|AL022860|AU019543|Bip|D2Wsu141e|D2Wsu17e|Grp78|Hsce70|SEZ-7|Sez7|mBiP

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 B|2 22.5 cM

Physical Location:

34627614-34631976 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3309 Symbol (Name): HSPA5 (heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa))

Ortholog Status:

The human GeneID 3309 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hspa5
Original ID2:		AJ002387

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcp1	Alcohol Preference Drinking	2	28	19-35 (cM)	5.3		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022310.2	NP_071705.2	NC_000068.6 range: 34627614..34631976

Gene Ontology (GO) Annotation