ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gss

Full Name:

glutathione synthetase

Alias:

AI314904|GS-A/GS-B

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 H1

Physical Location:

155388918-155418441 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2937 Symbol (Name): GSS (glutathione synthetase)

Ortholog Status:

The human GeneID 2937 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gss
Original ID2:		U35456

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008180.1	NP_032206.1	NC_000068.6 range: 155388918..155418441, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004363	glutathione synthase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0006750	glutathione biosynthetic process	Biological Process	IEA