ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hap1

Full Name:

huntingtin-associated protein 1

Alias:

HAP-1|MGC31449

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 D|11 60.0 cM

Physical Location:

100208640-100217400 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9001 Symbol (Name): HAP1 (huntingtin-associated protein 1)

Ortholog Status:

The human GeneID 9001 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hap1
Original ID2:		AJ002272

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010404.2	NP_034534.1	NC_000077.5 range: 100208640..100217400, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component	IDA (15242649)
GO:0005515	protein binding	Molecular Function	IPI (9599014\|15242649)
GO:0047496	vesicle transport along microtubule	Biological Process	IMP (15242649)