ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hars

Full Name:

histidyl-tRNA synthetase

Alias:

MMHRS

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 B2

Physical Location:

36926183-36942773 on NC_000084.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3035 Symbol (Name): HARS (histidyl-tRNA synthetase)

Ortholog Status:

The human GeneID 3035 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hars
Original ID2:		U39473

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008214.3	NP_032240.2	NC_000084.5 range: 36926183..36942773, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004812	aminoacyl-tRNA ligase activity	Molecular Function	IEA
GO:0004821	histidine-tRNA ligase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0006412	translation	Biological Process	IEA
GO:0006418	tRNA aminoacylation for protein translation	Biological Process	IEA
GO:0006427	histidyl-tRNA aminoacylation	Biological Process	IEA