ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hba-a1

Full Name:

hemoglobin alpha, adult chain 1

Alias:

Hba1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 A4|11 16.0 cM

Physical Location:

32183673-32184492 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3040 Symbol (Name): HBA2 (hemoglobin, alpha 2)

Ortholog Status:

The human GeneID 3040 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hba-a1
Original ID2:		AV003378

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008218.2	NP_032244.2	NC_000077.5 range: 32183673..32184492

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005833	hemoglobin complex	Cellular Component	IEA
GO:0005344	oxygen transporter activity	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0019825	oxygen binding	Molecular Function	IEA
GO:0001701	in utero embryonic development	Biological Process	IGI (7550311)
GO:0015671	oxygen transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0048821	erythrocyte development	Biological Process	IGI (7550311)