ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hbb-b1

Full Name:

hemoglobin, beta adult major chain

Alias:

AA409645|Hbbt1|Hbbt2

Organism:

Mus musculus (Mouse)

Chromosome:

7

Genetic Location:

7 E3|7 50.0 cM

Physical Location:

110961039-110962436 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hbb-b1
Original ID2:		J00413

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008220.3	NP_032246.2	NC_000073.5 range: 110961039..110962436, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005833	hemoglobin complex	Cellular Component	IDA (12127975)
GO:0005344	oxygen transporter activity	Molecular Function	IMP (12127975)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0019825	oxygen binding	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0015671	oxygen transport	Biological Process	IMP (12127975)
GO:0030097	hemopoiesis	Biological Process	IMP (12127975)

Other Database Cross Links

NCBI Entrez Gene:

MGI:

Ensembl:

ENSMUSG00000073940

dbSNP:

AceView: