ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hcn2

Full Name:

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

Alias:

BCNG2|HAC1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 C1

Physical Location:

79179378-79198852 on NC_000076.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 610 Symbol (Name): HCN2 (hyperpolarization activated cyclic nucleotide-gated potassium channel 2)

Ortholog Status:

The human GeneID 610 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hcn2
Original ID2:		AJ225122

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008226.2	NP_032252.1	NC_000076.5 range: 79179378..79198852

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0030552	cAMP binding	Molecular Function	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15564593)
GO:0005272	sodium channel activity	Molecular Function	IEA
GO:0005267	potassium channel activity	Molecular Function	IEA
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0042391	regulation of membrane potential	Biological Process	IDA (15564593)
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0042391	regulation of membrane potential	Biological Process	IGI (15564593)