ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hmgb3

Full Name:

high mobility group box 3

Alias:

Hmg2a|Hmg4

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X A1

Physical Location:

68809167-68813828 on NC_000086.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3149 Symbol (Name): HMGB3 (high-mobility group box 3)

Ortholog Status:

The human GeneID 3149 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hmgb3
Original ID2:		AW060179

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008253.3	NP_032279.1	NC_000086.6 range: 68809167..68813828

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000785	chromatin	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (12714519)
GO:0005694	chromosome	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0045578	negative regulation of B cell differentiation	Biological Process	IDA (12714519)
GO:0045638	negative regulation of myeloid cell differentiation	Biological Process	IDA (12714519)