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Gene Information
Gene ID:15354
Symbol:Hmgb3
Full Name:high mobility group box 3
Alias:Hmg2a|Hmg4
Organism:Mus musculus (Mouse)
Chromosome:X
Genetic Location:X A1
Physical Location:68809167-68813828 on NC_000086.6
Gene Type:protein-coding
Human Ortholog:GeneID: 3149    Symbol (Name): HMGB3 (high-mobility group box 3)
Ortholog Status:The human GeneID 3149 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hmgb3
Original ID2:AW060179
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008253.3NP_032279.1NC_000086.6 range: 68809167..68813828
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000785chromatinCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (12714519)
GO:0005694chromosomeCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0045578negative regulation of B cell differentiationBiological ProcessIDA (12714519)
GO:0045638negative regulation of myeloid cell differentiationBiological ProcessIDA (12714519)
Other Database Cross Links
NCBI Entrez Gene:15354
MGI:
Ensembl:ENSMUSG00000015217
dbSNP:Hmgb3
AceView:Hmgb3