ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nr4a1

Full Name:

nuclear receptor subfamily 4, group A, member 1

Alias:

GFRP1|Gfrp|Hbr-1|Hbr1|Hmr|N10|NGFI-B|NGFIB|NP10|TIS1|TR3|nur77

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 F

Physical Location:

101097292-101105222 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3164 Symbol (Name): NR4A1 (nuclear receptor subfamily 4, group A, member 1)

Ortholog Status:

The human GeneID 3164 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nr4a1
Original ID2:		X16995

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010444.1	NP_034574.1	NC_000081.5 range: 101097292..101105222

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12815108)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0030528	transcription regulator activity	Molecular Function	IDA (14657025)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15155786\|15701640)
GO:0004879	ligand-dependent nuclear receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0003707	steroid hormone receptor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15155786\|15701640)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (15155786)
GO:0045449	regulation of transcription	Biological Process	IDA (14657025)
GO:0043154	negative regulation of caspase activity	Biological Process	IDA (12815108)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	IDA (14657025)