ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dnaja1

Full Name:

DnaJ (Hsp40) homolog, subfamily A, member 1

Alias:

Hsj2|Nedd7

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 A5

Physical Location:

40669565-40681996 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3301 Symbol (Name): DNAJA1 (DnaJ (Hsp40) homolog, subfamily A, member 1)

Ortholog Status:

The human GeneID 3301 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dnaja1
Original ID2:		AF055664

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008298.4	NP_032324.1	NC_000070.5 range: 40669565..40681996

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0051082	unfolded protein binding	Molecular Function	IEA
GO:0050750	low-density lipoprotein receptor binding	Molecular Function	ISS (15082773)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0031072	heat shock protein binding	Molecular Function	IEA
GO:0030521	androgen receptor signaling pathway	Biological Process	IMP (15660130)
GO:0030317	sperm motility	Biological Process	IMP (15660130)
GO:0007283	spermatogenesis	Biological Process	IMP (15660130)
GO:0006457	protein folding	Biological Process	IEA