ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

15531

Symbol:

Ndst1

Full Name:

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

Alias:

1200015G06Rik|Hsst|NDST-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 D2

Physical Location:

60845616-60873042 on NC_000084.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3340 Symbol (Name): NDST1 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1)

Ortholog Status:

The human GeneID 3340 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ndst1
Original ID2:		AI844370

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008306.4	NP_032332.2	NC_000084.5 range: 60845616..60873042, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity	Molecular Function	TAS (10664446\|10852901)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0008146	sulfotransferase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0030203	glycosaminoglycan metabolic process	Biological Process	IMP (16020517)
GO:0030900	forebrain development	Biological Process	IGI (16020517)
GO:0030900	forebrain development	Biological Process	IMP (16020517)
GO:0030901	midbrain development	Biological Process	IGI (16020517)
GO:0048702	embryonic neurocranium morphogenesis	Biological Process	IMP (16020517)
GO:0000165	MAPKKK cascade	Biological Process	IMP (16020517)
GO:0009887	organ morphogenesis	Biological Process	IMP (10664446\|10852901)
GO:0000271	polysaccharide biosynthetic process	Biological Process	IMP (10852901)
GO:0006476	protein amino acid deacetylation	Biological Process	TAS (10664446\|10852901)
GO:0006477	protein amino acid sulfation	Biological Process	IMP (10852901)
GO:0006477	protein amino acid sulfation	Biological Process	TAS (10664446)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0007224	smoothened signaling pathway	Biological Process	IGI (16020517)
GO:0007585	respiratory gaseous exchange	Biological Process	IMP (10664446\|10852901)
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	IMP (16020517)
GO:0009790	embryonic development	Biological Process	IGI (16020517)
GO:0048703	embryonic viscerocranium morphogenesis	Biological Process	IMP (16020517)