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Gene Information
Gene ID:15567
Full Name:solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Organism:Mus musculus (Mouse)
Genetic Location:11 B5|11 42.0 cM
Physical Location:76812098-76845842 on NC_000077.5
Gene Type:protein-coding
Human Ortholog:GeneID: 6532    Symbol (Name): SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)
Ortholog Status:The human GeneID 6532 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Slc6a4
Fold Change:0.63
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Lore4Alcohol-induced Loss of Righting Reflex11 36-42 (cM)6.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010484.1NP_034614.1NC_000077.5 range: 76812098..76845842
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentIEA
GO:0015293symporter activityMolecular FunctionIEA
GO:0008504monoamine transmembrane transporter activityMolecular FunctionISS (16024787)
GO:0005335serotonin:sodium symporter activityMolecular FunctionIEA
GO:0005328neurotransmitter:sodium symporter activityMolecular FunctionIEA
GO:0006836neurotransmitter transportBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0015844monoamine transportBiological ProcessISS (16024787)
Other Database Cross Links
NCBI Entrez Gene:15567