ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc6a4

Full Name:

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Alias:

5-HTT|AI323329|Htt|MGC124313|MGC124314|Sert

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B5|11 42.0 cM

Physical Location:

76812098-76845842 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6532 Symbol (Name): SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Ortholog Status:

The human GeneID 6532 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Slc6a4
Fold Change:		0.63
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore4	Alcohol-induced Loss of Righting Reflex	11		36-42 (cM)	6.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010484.1	NP_034614.1	NC_000077.5 range: 76812098..76845842

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	IEA
GO:0015293	symporter activity	Molecular Function	IEA
GO:0008504	monoamine transmembrane transporter activity	Molecular Function	ISS (16024787)
GO:0005335	serotonin:sodium symporter activity	Molecular Function	IEA
GO:0005328	neurotransmitter:sodium symporter activity	Molecular Function	IEA
GO:0006836	neurotransmitter transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0015844	monoamine transport	Biological Process	ISS (16024787)