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Gene Information
Gene ID:6532
Full Name:solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Organism:Homo sapiens (Human)
Genetic Location:17q11.1-q12
Physical Location:25549031-25586840 on NC_000017.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 15567 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:SLC6A4
Dataset Information
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:SLC6A4
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
SLC6A41Alcohol Intoxication
SLC6A43Alcohol-Induced Disorders
SLC6A41Alcohol-Induced Disorders Nervous System
SLC6A438Alcohol-Related Disorders
SLC6A41Alcohol Withdrawal Delirium
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001045.3NP_001036.1NC_000017.9 range: 25549031..25586840, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (7681602)
GO:0015293symporter activityMolecular FunctionIEA
GO:0015222serotonin transmembrane transporter activityMolecular FunctionTAS (7681602)
GO:0008504monoamine transmembrane transporter activityMolecular FunctionIDA (16024787)
GO:0005515protein bindingMolecular FunctionIPI (11343649)
GO:0005335serotonin:sodium symporter activityMolecular FunctionIEA
GO:0006837serotonin transportBiological ProcessTAS (7681602)
GO:0015844monoamine transportBiological ProcessIDA (16024787)
GO:0001504neurotransmitter uptakeBiological ProcessTAS (7681602)
Other Database Cross Links
NCBI Entrez Gene:6532
HuGE Navigator:6532