ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Elavl4

Full Name:

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

Alias:

Elav|Hud|PNEM

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C7|4 49.5 cM

Physical Location:

109876341-109960115 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1996 Symbol (Name): ELAVL4 (ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D))

Ortholog Status:

The human GeneID 1996 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Elavl4
Original ID2:		D31953

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws2	Chronic Alcohol Withdrawal	4		33-51 (cM)	2.3	0.005	Significant	PARC

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation