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Gene Information
Gene ID:1593
Full Name:cytochrome P450, family 27, subfamily A, polypeptide 1
Organism:Homo sapiens (Human)
Genetic Location:2q33-qter
Physical Location:219354948-219388258 on NC_000002.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 104086 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.516700
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:CYP27A1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000784.3NP_000775.1NC_000002.10 range: 219354948..219388258
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIEA
GO:0005759mitochondrial matrixCellular ComponentEXP (1708392)
GO:0016020membraneCellular ComponentIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0020037heme bindingMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionIEA
GO:0008395steroid hydroxylase activityMolecular FunctionTAS (9790667)
GO:0008395steroid hydroxylase activityMolecular FunctionEXP (1708392)
GO:0047749cholestanetriol 26-monooxygenase activityMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:1593
HuGE Navigator:1593