ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DAXX

Full Name:

death-associated protein 6

Alias:

BING2|DAP6|MGC126245|MGC126246

Organism:

Homo sapiens (Human)

Chromosome:

6

Genetic Location:

6p21.3

Physical Location:

33394366-33398681 on NC_000006.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.336916
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001350.3	NP_001341.1	NC_000006.10 range: 33394366..33398681, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (15572661)
GO:0005737	cytoplasm	Cellular Component	TAS (15572661)
GO:0005057	receptor signaling protein activity	Molecular Function	TAS (9215629)
GO:0047485	protein N-terminus binding	Molecular Function	IPI (15572661)
GO:0042802	identical protein binding	Molecular Function	IPI (10698492)
GO:0031072	heat shock protein binding	Molecular Function	TAS (15572661)
GO:0050681	androgen receptor binding	Molecular Function	IPI (15572661)
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA (15572661)
GO:0007257	activation of JNK activity	Biological Process	TAS (9215629)
GO:0006915	apoptosis	Biological Process	TAS (15572661)
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (15572661)
GO:0006350	transcription	Biological Process	IEA
GO:0008625	induction of apoptosis via death domain receptors	Biological Process	TAS (9215629)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000204209

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: