ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

16189

Symbol:

Il4

Full Name:

interleukin 4

Alias:

IgG1|Il-4

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B1.3|11 29.0 cM

Physical Location:

53425969-53432166 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3565 Symbol (Name): IL4 (interleukin 4)

Ortholog Status:

The human GeneID 3565 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws4/Alcw3	Chronic Alcohol Withdrawal	11		15-36 (cM)	6.7	2.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021283.1	NP_067258.1	NC_000077.5 range: 53425969..53432166, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IDA (11057672\|16275384\|16769892)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005125	cytokine activity	Molecular Function	IDA (1588041\|10485657\|10979977\|11027433)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (8266076)
GO:0005136	interleukin-4 receptor binding	Molecular Function	IEA
GO:0005126	hematopoietin/interferon-class (D200-domain) cytokine receptor binding	Molecular Function	IEA
GO:0045671	negative regulation of osteoclast differentiation	Biological Process	IDA (12941478)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (1588041)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (9110977)
GO:0048295	positive regulation of isotype switching to IgE isotypes	Biological Process	IDA (14988498)
GO:0048304	positive regulation of isotype switching to IgG isotypes	Biological Process	IDA (12882831\|14988498)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA (8022486)
GO:0050776	regulation of immune response	Biological Process	IDA (12882831)
GO:0045348	positive regulation of MHC class II biosynthetic process	Biological Process	IDA (11027433)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA (10429671)
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	Biological Process	IDA (10485657)
GO:0042325	regulation of phosphorylation	Biological Process	IDA (12115603)
GO:0042113	B cell activation	Biological Process	IEA
GO:0042104	positive regulation of activated T cell proliferation	Biological Process	IDA (10485657)
GO:0042102	positive regulation of T cell proliferation	Biological Process	IDA (1588041)
GO:0030890	positive regulation of B cell proliferation	Biological Process	IDA (10979977)
GO:0008203	cholesterol metabolic process	Biological Process	IMP (11971948)
GO:0006955	immune response	Biological Process	IEA
GO:0050871	positive regulation of B cell activation	Biological Process	IDA (8566034)