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Gene Information
Gene ID:1636
Full Name:angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Organism:Homo sapiens (Human)
Genetic Location:17q23.3
Physical Location:58908165-58928710 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has Fly: 34805 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ACE
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
ACE1Alcohol Amnestic Disorder
ACE3Alcohol-Induced Disorders
ACE1Alcohol-Induced Disorders Nervous System
ACE5Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000789.2NP_000780.1NC_000017.9 range: 58908165..58928710
NM_152830.1NP_690043.1NC_000017.9 range: 58908165..58928710
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentNAS
GO:0016021integral to membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentNAS (2547653)
GO:0005886plasma membraneCellular ComponentTAS (10748135)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentTAS (1328889)
GO:0005624membrane fractionCellular ComponentTAS (2849100)
GO:0005576extracellular regionCellular ComponentIEA
GO:0016798hydrolase activity, acting on glycosyl bondsMolecular FunctionIEA
GO:0031404chloride ion bindingMolecular FunctionIEA
GO:0004180carboxypeptidase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0004246peptidyl-dipeptidase A activityMolecular FunctionTAS (2547653|2554286)
GO:0004246peptidyl-dipeptidase A activityMolecular FunctionIEA
GO:0008217regulation of blood pressureBiological ProcessTAS (1328889)
GO:0006508proteolysisBiological ProcessTAS (1649623|2554286)
GO:0006508proteolysisBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:1636
HuGE Navigator:1636