ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ACE

Full Name:

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Alias:

ACE1|CD143|DCP|DCP1|MGC26566

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q23.3

Physical Location:

58908165-58928710 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 34805 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ACE

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
ACE	1	Alcohol Amnestic Disorder
ACE	3	Alcohol-Induced Disorders
ACE	1	Alcohol-Induced Disorders Nervous System
ACE	4	Alcoholism
ACE	5	Alcohol-Related Disorders

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	NAS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	NAS (2547653)
GO:0005886	plasma membrane	Cellular Component	TAS (10748135)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005625	soluble fraction	Cellular Component	TAS (1328889)
GO:0005624	membrane fraction	Cellular Component	TAS (2849100)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0016798	hydrolase activity, acting on glycosyl bonds	Molecular Function	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0004180	carboxypeptidase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004246	peptidyl-dipeptidase A activity	Molecular Function	TAS (2547653\|2554286)
GO:0004246	peptidyl-dipeptidase A activity	Molecular Function	IEA
GO:0008217	regulation of blood pressure	Biological Process	TAS (1328889)
GO:0006508	proteolysis	Biological Process	TAS (1649623\|2554286)
GO:0006508	proteolysis	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA