ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ance

Alias:

ACE|BG:DS08220.3|CG8827|RACE|anon-EST:fe3D10|br31|l(2)34Eb|l(2)br31|l34Eb|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

34E2-34E2

Physical Location:

13905644-13909171 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1636 Symbol (Name): ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)

Ortholog Status:

The human GeneID 1636 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	NAS
GO:0008270	zinc ion binding	Molecular Function	NAS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0004246	peptidyl-dipeptidase A activity	Molecular Function	IDA (7775412)
GO:0004246	peptidyl-dipeptidase A activity	Molecular Function	TAS (10961941)
GO:0004246	peptidyl-dipeptidase A activity	Molecular Function	NAS
GO:0006508	proteolysis	Biological Process	IEA
GO:0007291	sperm individualization	Biological Process	IMP (12591244)
GO:0007552	metamorphosis	Biological Process	IEP (12093364)
GO:0007289	spermatid nuclear differentiation	Biological Process	IMP (12591244)