ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Kcnd2

Full Name:

potassium voltage-gated channel, Shal-related family, member 2

Alias:

AI839615|AW555701|Kv4.2|R75121|mKIAA1044

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 A2-A3.1|6 7.2 cM

Physical Location:

21166108-21679804 on NC_000072.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3751 Symbol (Name): KCND2 (potassium voltage-gated channel, Shal-related subfamily, member 2)

Ortholog Status:

The human GeneID 3751 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Kcnd2
Original ID2:		AI839615

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019697.3	NP_062671.1	NC_000072.5 range: 21166108..21679804

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16257958)
GO:0005267	potassium channel activity	Molecular Function	IEA
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0006813	potassium ion transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA