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Gene Information
Gene ID:16508
Full Name:potassium voltage-gated channel, Shal-related family, member 2
Organism:Mus musculus (Mouse)
Genetic Location:6 A2-A3.1|6 7.2 cM
Physical Location:21166108-21679804 on NC_000072.5
Gene Type:protein-coding
Human Ortholog:GeneID: 3751    Symbol (Name): KCND2 (potassium voltage-gated channel, Shal-related subfamily, member 2)
Ortholog Status:The human GeneID 3751 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Kcnd2
Original ID2:AI839615
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019697.3NP_062671.1NC_000072.5 range: 21166108..21679804
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0008076voltage-gated potassium channel complexCellular ComponentIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (16257958)
GO:0005267potassium channel activityMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIEA
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0006813potassium ion transportBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:16508