ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rasgrp4

Full Name:

RAS guanyl releasing protein 4

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q21

Physical Location:

84265740-84284683 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 115727 Symbol (Name): RASGRP4 (RAS guanyl releasing protein 4)

Ortholog Status:

The human GeneID 115727 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rasgrp4
Fold Change:		-1.14
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_130824.2	NP_570837.2	NC_005100.2 range: 84265740..84284683

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0005625	soluble fraction	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Molecular Function	ISS
GO:0019992	diacylglycerol binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0008283	cell proliferation	Biological Process	ISS
GO:0009991	response to extracellular stimulus	Biological Process	ISS
GO:0016049	cell growth	Biological Process	ISS
GO:0030154	cell differentiation	Biological Process	IEA
GO:0046579	positive regulation of Ras protein signal transduction	Biological Process	ISS
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process	IEA