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Gene Information
Gene ID:170924
Symbol:Abcc4
Full Name:ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Alias:Mrp4
Organism:Rattus norvegicus (Rat)
Chromosome:15
Genetic Location:15q24
Physical Location:103384847-103611237 on NC_005114.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10257    Symbol (Name): ABCC4 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)
Ortholog Status:The human GeneID 10257 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Abcc4
Fold Change:1.19
P Value:0.005
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Abcc4
Fold Change:1.24
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_133411.1NP_596902.1NC_005114.2 range: 103384847..103611237, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0031088platelet dense granule membraneCellular ComponentISS
GO:0005624membrane fractionCellular ComponentISS
GO:0005886plasma membraneCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016887ATPase activityMolecular FunctionIEA
GO:0042626ATPase activity, coupled to transmembrane movement of substancesMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005254chloride channel activityMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:170924
RGD:620266
Ensembl:ENSRNOG00000010064
dbSNP:Abcc4