ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Abcc4

Full Name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Alias:

Mrp4

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

15q24

Physical Location:

103384847-103611237 on NC_005114.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10257 Symbol (Name): ABCC4 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)

Ortholog Status:

The human GeneID 10257 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Abcc4
Fold Change:		1.19
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Abcc4
Fold Change:		1.24
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133411.1	NP_596902.1	NC_005114.2 range: 103384847..103611237, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031088	platelet dense granule membrane	Cellular Component	ISS
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016887	ATPase activity	Molecular Function	IEA
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005254	chloride channel activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA